Surgery For Metastatic and High-Risk PCa

Edward Schaeffer, MD, PhD, Urology

Edward Schaeffer, MD, PhD, Urology

Dr. Edward Schaeffer is the Chair of the departments of Urology a Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital.

In July, Prostatepedia spoke with him about the advances in urology. Subscribe to read the entire conversation.

What are the current thoughts on the role of surgery for recurrent oligometastatic disease? [Oligometastatic disease means you only have three to five metastatic lesions outside of the prostate gland.]

Dr. Edward Schaeffer: Many surgeons and patients are enthusiastic about aggressively treating oligometastatic prostate cancer. I’m also enthusiastic about the possibility that this approach could help patients. But I think it is very important for patients reading this interview to understand that these kinds of studies are totally experimental; we do not know yet if these approaches will benefit men. Although I’m personally enthusiastic about these kinds of approaches—and am the principal investigator on a study exploring this called the TED trial. (TED stands for Trimodal Elimination of Disease and uses surgery, radiation, and systemic [chemo-hormonal] therapy to eliminate all visible evidence of prostate cancer.) However, I really only recommend that the average patient seek treatment for their oligometastatic or recurrent prostate cancer in the setting of a clinical trial. This is really experimental. We don’t know if it helps and it may actually hurt people—this is why it needs to be done as a trial.

Is there any controversy over surgically treating the primary tumor when a man’s cancer has already spread outside the prostate gland?

Dr. Schaeffer: No, I don’t think there is any controversy in that. If you mean is there controversy in over-treating the prostate if a man has ogliometastatic disease, then yes, that is controversial. But in my mind, surgery benefits most men with large bulky high-grade cancers. Radiation is less effective in those cases.

In the last three to four years in my practice, I’ve seen more and more men with more advanced high-grade bulky cancers. I believe, although this hasn’t been shown in a randomized clinical trial, that the best way to manage these cancers is the way we manage many other cancers: a multimodal approach of surgery followed by radiation and potentially chemotherapy.

Why do you think more and more people are being diagnosed with bulky high-grade disease?

Dr. Schaeffer: Several reasons. One, the United States Preventive Services Task Force (USPSTF) changed their recommendations in 2008 for men over 75 and in 2012 for men under 75 for PSA screening. It’s well documented that there have been relaxations in PSA screening and that relaxations in PSA screening have resulted in fewer biopsies.

Think about the natural history of prostate cancer: if you had an aggressive localized cancer and left it alone for five to seven years, it would come back as a bulky aggressive cancer most probably involving the lymph nodes or beyond.

And that is exactly what we’ve seen. Dr. Jim Hu published that exact observation in JAMA Oncology in December 2016. Unfortunately, we’ve now proved that what we thought would happen did in fact happen. The screening recommendations are not to the benefit of the patient. Fortunately, the USPSTF recently revised their recommendations and now suggest that PSA screening is something that physicians should bring up and discuss with their patients. This is a big step in the right direction.


2 Comment

Peter Preston

@ age 53 diagnosed PCA Gleason 5+4 PSA 23,August 2009, RARP. Oct 2009, PSA 7.6, casodex started.2/2010 PSA 0.1. 3/2010 Avodart started. 9/2010 PSA climbs, Casodex stopped, Niludamide started. IMRT 12/2010 til1/2011. Lupron 28 day started. PSA 0.01. 10/2011, Lupron & niludamide stopped November 2011, March 2012, PSA0.01, April 2012 PSA 0.02, May0.03 June 0.06 July 0.14 (doubling time now approx 20 days). August recommenced Avodart + Zytiga/prednisone.September 2012 psa 0.01. Xgeva started April 2014 to date monthly,April 2015, Provenge treatment, June 2015 – Nov 2015 Xofigo course. Since August 2012 PSA remains at 0.01 and testosterone <17 to current date. Health generally very good, some hip pain and general fatigue. From 2009, 3 lesions detectable on ribs. Some dietary restrictions – minimal dairy, eggs, red meat, but not too strict…
Would appreciate feedback as three doctors have expressed surprise at my continued survival and good health.

Posted: Jul 29, 2017

Clark Maxfield

What happened to Dr WJ Catalona? Did he retire from Northwestern Memorial Hospital as head of the Urology department?

Posted: Jul 29, 2017

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