POSTED: June 29, 2016

Aspirin + Prostate Cancer

Dr. Snuffy Myers talks about aspirin + prostate cancer.

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Here are the references Dr. Myers mentions during his talk:

1. Precision prevention of TMPRSS2:ERG prostate cancer. Lorelei A. Mucci,  Thomas Ahearn, Kathryn Penney, Andreas Pettersson, Rebecca E Graff, Philip W. Kantoff, Stephen Finn, Massimo Loda, and Transdisciplinary Prostate Cancer Partnership. ASCO MEETING ABSTRACTS Jan 25, 2016:78

2. Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2:ERG fusion status. J L Wright, L Chéry, S Holt, D W Lin, M Luedeke, A E Rinckleb, C Maier and J L Stanford. Prostate Cancer Prostatic Dis 19: 53-56; advance online publication, October 27, 2015; doi:10.1038/pcan.2015.49


ASPIRIN AND PROSTATE CA

6 Comment

HMM

I agree about the mixed results in the literature with aspirin related to PC, but it appears to me when drilling down into the studies that the effectiveness of aspirin improves in those patients considered to be “high risk”.

Furthermore, aspirin doesn’t prevent, but it does appear to slow metastasis. In the citation below, dated January 2016…(Dr Allard was speaking at a press briefing held in advance of the Genitourinary Cancers Symposium 2016 in San Francisco.)

In men with prostate cancer, regular aspirin use is associated with a slower rate of disease progression and a reduced risk of dying from the disease, according to a new study.

The findings come from an analysis of data from the large prospective Physicians’ Health Study, in which 3193 men developed prostate cancer over a 27-year period. Of these cancers, 403 were lethal, defined as metastatic disease or death from prostate cancer.

But the risk developing lethal prostate cancer was 24% lower in men who took aspirin on a regular basis, …
“Men with prostate cancer who took aspirin regularly had a 39% lower risk of dying from prostate cancer,” said Dr Allard.

However, aspirin use did not measurably reduce the overall incidence of prostate cancer. It also did not prevent high-grade cancers or locally advanced prostate cancers, Dr Allard noted.

“We found that aspirin intake before prostate cancer diagnosis was not beneficial,”

Quoted from MEDSCAPE, July 1, 2016.

From the NCI data base archive…
In 2011, for example, a meta-analysis of eight randomized clinical trials that compared the risk of cancer death among participants who took daily aspirin for 4 years or more and those who took no aspirin found that, overall, aspirin use lowered the risk of dying from cancer by approximately 20 percent.

By looking at data from individual participants in these trials, the researchers, led by Peter Rothwell, M.D., Ph.D., FRCP, of the University of Oxford, showed that this risk reduction was due mainly to fewer cancer deaths among participants who took aspirin for at least 5 years. The largest drop in risk was for gastrointestinal cancers, particularly colorectal cancer. The study also showed more modest risk reductions for several other common cancers, including lung and prostate.

Posted: Jul 01, 2016

Andre Paquin

Thanks for sharing this POV. I am an active surveillance candidate and I also take a daily low dose aspirin. My cardiologist suggested I take this daily because of the family history of heart disease. I’m also on medications for hypertension and to manage my cholesterol as well. I’ve always assumed that the daily regimen of aspirin acted as a blood thinning agent so that my arteries would be less susceptible to plaque build up and the cholesterol issues my mom suffered from as well as heart disease.

I will discuss this with my cardiologist, but I’m curious if you have any insight as to why low dose aspirin is prescribed and do the benefits to managing heart disease outweigh any side effects it may have with regard to my prostate cancer.

Any insight would be helpful. Thanks.

Posted: Jun 30, 2016

JOE HAGEDORN

I decided to stop aspirin after 2012 when I started Coumadin. I already had bleeding from prostate radiation while on aspirin, but when I started Coumadin which has further risk of bleeding and stroke, I did not want to have the risk of bleeding from aspirin too. So I told my cardiologist I was stopping aspirin too. It is hard enough to control Coumadin INR levels with diet.

Posted: Jun 30, 2016

Loyson Schneider

Does the aspirin danger apply to all or just the “normal” 325 grain dose? I.E. does it apply to daily taking 81 grain enteric aspirin routinely given as a means to assist older patients with blood thinning even though they have not had major heart issues?

Posted: Jun 29, 2016

Andy Graybar

Snuffy, What about two glasses of White Wine a day, or two glasses of Red Wine ?

Posted: Jun 29, 2016

bob ferra

As an elderly male (69) I have been diagnosed with CVC —Calcium score of 475. I also had my prostate removed about a year ago to treat an aggressive cancer which was not contained in the capsule. My doctor feels he got it just in time-I’m hoping he’s right.
My cardiologist insists that I take low dose aspirin because of its anti inflammatory properties. From much that I have read it seems that inflammation is widely thought to contribute to the development of cancer. Is that a correct assumption on my part? And, if so, would it not make sense, risk factors aside, that anything that would counter inflammation would be of some benefit?

Posted: Jun 29, 2016

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