What role does Lupron play in hormonal therapy?

Lupron is used to suppress serum testosterone levels. The goal is to reduce the serum testosterone level low enough to match what would be achieved with the surgical removal of the testicles (i.e. castration). The advantage of Lupron over surgical castration are that you avoid surgery. Plus, when you stop taking Lupron your testosterone can then return to normal.

There are three Lupron competitors: Eligard, Trelstar, and Zoladex. Any one of these four drugs can get the job done, but most physicians have a favorite and will stock that drug in favor of the others. Every so often, a patient will be unable to tolerate one of these drugs, sometimes due to an allergic reaction. It is nice to have other options.

This question appeared in Prostate Forum Volume 11 Number 7.


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